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ADVA-SPHERA™ TECHNOLOGY

Micronutrient-targeted technology accelerates delivery of time-released active ingredients in the body with improved bioavailability, absorption and stability.

WHAT IS A LIQUID CAPSULE?

Whether prescription medication or dietary supplements, you have likely taken tablets, capsules and softgels. But all have limitations by nature of their form. Now imagine taking the best properties of all forms and combining into something so innovative and effective that multiple pharmaceutical applications are in development.

A liquid capsule is a hard shell capsule containing liquid or liquid + beadlets resulting in a highly efficacious delivery system. The unique combination of both liquid and beadlets allows for ingredients to be in both forms, therefore controlling the release and absorption of the active ingredients. While liquid is absorbed more quickly into the bloodstream through the gastrointestinal system, the ingredients contained in beadlets release according to the intended release rate.

ADVANTAGES OF LIQUID CAPSULES

Absorption

Compared to oral solid forms, such as tablets and powder capsules, liquid-filled capsules begin the dissolution process in as little as 5 minutes and complete within 15 minutes. Even softgels require much longer for dissolution due to the thickness of its gelatin wall. Liquid forms of ingredients can also be more absorbable by nature of being less dense and entering the bloodstream more easily.

Bioavailability

Faster and more consistent dissolution of the liquid and Adva-Sphera™ beadlets improve bioavailability, resulting in enhanced efficacy. MCT (medium-chain triglyceride) oil, a water-soluble oil more bioavailable than fat-soluble carriers, is often combined with other nutrients in liquid form, making all the ingredients of the liquid capsule more bioavailable.

Stability

Enhanced stability of the active ingredients contained within liquid-filled hard capsules are key to efficacy. Heat and odor resistance are testament to the superior preservation of nutrients. A leakproof seal also ensures the protection of ingredients and tamper evidence.

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WHY ARE LIQUID CAPSULES BETTER THAN OTHER FORMS?

Tablets and Powder-filled Capsules are the most common form of dosage, but can be abrasive, slow to absorb, lack bioavailability if not digested with fat-soluble oils and sensitive to degradation from light or heat. Furthermore, both often contain excipients and additives.

Softgels (soft gelatin capsules) are a soft-shelled capsule shell containing liquid. While the liquid form of active ingredients can have enhanced absorption, this benefit can be negated by nature of the thick capsule shell requiring more time to dissolve in the stomach. In addition, combination filling is not possible, higher oxygen permeability shortens shelf-life and synthetic ingredients, such as plasticizers, are common in softgels.

Liquid and Powder dietary supplements have gained traction recently with claims of better absorption. However, both lack the capability to time-release or be easily administered or transported given the nature of their form.